• Users Online: 94
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 


 
 Table of Contents  
CASE REPORT
Year : 2022  |  Volume : 34  |  Issue : 2  |  Page : 157-160

Peripheral ulcerative keratitis with multiple punctate scleral abscess – A rare presentation of ocular tuberculosis


Department of Ophthalmology, Government Medical College, Kozhikode, Kerala, India

Date of Submission29-Oct-2021
Date of Decision26-Jan-2022
Date of Acceptance08-Apr-2022
Date of Web Publication30-Aug-2022

Correspondence Address:
Dr. I Karthiga
The Kerala state housing board, working womens hostel, chevayur, Kozhikode 673017, Kerala
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/kjo.kjo_214_21

Rights and Permissions
  Abstract 


This case report represents an unusual presentation of ocular tuberculosis (TB). Ocular TB is rare, but it can be the first clinical manifestation of the disease. Here, we report a case of a 67-year-old male, a chronic smoker who presented with pain, redness, and photophobia (BE), and slit-lamp examination showed multiple corneal infiltrate along the limbus with multiple scleral abscesses not responding to routine treatment. Investigations revealed high erythrocyte sedimentation rate value, positive Mantoux reaction, and changes on contrast-enhanced computed tomography of the thorax. Sputum CBNAAT was negative, and pus aspirate revealed no growth with negative staining for acid-fast bacillus. With high suspicion of TB, we started on Anti tuberculosis therapy, and there was rapid healing of lesions. In endemic areas, even when microbiological studies are not positive, ocular TB should be kept in mind in atypical cases so that early treatment can be instituted to prevent serious complications.

Keywords: ATT, ocular tuberculosis, peripheral ulcerative keratitis, scleral abscess


How to cite this article:
Karthiga I, Solomon CB, Konnakkodan SM, Babitha V, Kumar A A. Peripheral ulcerative keratitis with multiple punctate scleral abscess – A rare presentation of ocular tuberculosis. Kerala J Ophthalmol 2022;34:157-60

How to cite this URL:
Karthiga I, Solomon CB, Konnakkodan SM, Babitha V, Kumar A A. Peripheral ulcerative keratitis with multiple punctate scleral abscess – A rare presentation of ocular tuberculosis. Kerala J Ophthalmol [serial online] 2022 [cited 2022 Dec 4];34:157-60. Available from: http://www.kjophthal.com/text.asp?2022/34/2/157/355048




  Introduction Top


India is the highest tuberculosis (TB) burden country in the world, having an estimated incidence of 26.9 lakh cases in 2019 (WHO). Pulmonary TB is responsible for 80% of the active systemic disease, the remaining 20% of the disease may affect other organs, including the eye.[1]

Ocular TB is rare, but it can be the first clinical manifestation of the disease.

Due to the rare occurrence of the disease, difficulty in detecting the bacillus, and the low suspicion index, diagnosis can be delayed leading to complications with high morbidity. Therefore, early diagnosis and treatment plays an important role.[2]

Here, we report a case of bilateral peripheral ulcerative keratitis (PUK) associated with multiple punctate scleral abscess with probable etiology of TB.


  Case Report Top


A 67-year-old male, a chronic smoker with no comorbidities, presented to the outpatient department with pain, redness, and photophobia for duration of 5 days in the right eye and 3 days in the left eye. He had no history of trauma with any vegetative matter.

General and systemic examinations were within normal limits.

On examination, BCVA was 6/12 (OD) and 6/9(OS).

Slit-lamp examination of the right eye showed lid edema with circumcorneal congestion, cornea showed multiple 2 mm × 1 mm epithelial defects with underlying infiltrate, well-circumscribed margins along the limbus from 4 to 7 o'clock position extending up to anterior stroma with surrounding stromal edema. AC showed cells 2+, flare 1+ [Figure 1]. The left eye also showed lid edema with circumcorneal congestion; cornea showed two 2 mm × 1 mm epithelial defects with underlying infiltrate, well-circumscribed margins at 7 and 8 o'clock position along the limbus extending up to anterior stroma with surrounding stromal edema. AC showed cells 1+, flare 1+ [Figure 2]. Indirect ophthalmoscopic examination of both eyes was normal.
Figure 1: (a), (b), (c) Slit-lamp findings of the right eye showing multiple corneal infiltrate with punctate scleral abscess

Click here to view
Figure 2: (a), (b), (c) Slit-lamp findings of the left eye showing corneal infiltrate with scleral abscess

Click here to view


Routine investigations revealed a high erythrocyte sedimentation rate of 116 mm/h; Mantoux was highly positive. Routine smear and culture of infiltrate were negative. Chest X-ray showed increased bronchovascular markings. Contrast-enhanced computed tomography of the thorax showed tree in bud appearance, which is a characteristic feature of TB [Figure 3]. However, sputum CBNAAT was negative.
Figure 3: Contrast-enhanced computed tomography of the thorax showing a tree in bud appearance

Click here to view


Meanwhile, during the course in the hospital, the patient developed multiple punctate scleral abscess and the corneal lesions remain unchanged in both eyes.

The patient was treated with systemic and topical antibiotics; scleral abscess aspirate sent for routine culture showed no growth. Acid-fast bacillus (AFB) staining was negative for bacilli, and polymerase chain reaction (PCR) could not be done due to an insufficient sample.

A high index of suspicion along with supporting investigations led us to a provisional diagnosis of PUK with scleral abscess – probable etiology of TB.

The patient was started on ATT after pulmonology evaluation. There was a symptomatic and clinical improvement with rapid healing of lesions vindicating our stand [Figure 4].
Figure 4: Findings showing healing of lesions. (a) right eye (b) left ey

Click here to view



  Discussion Top


TB is caused by Mycobacterium tuberculosis, one of the major causes of morbidity and mortality worldwide. Ocular TB is the infection by M. tuberculosis in the eye, around the eye, or its surface.

Ocular TB may not be usually associated with clinical evidence of pulmonary TB, as up to 60% of extrapulmonary TB patients do not have pulmonary TB.[3]

Incidence of ocular TB ranges from 1.4% to 5.74%; however, in an endemic region, it may reach up to 10%.[4]

Thirteen to fourteen thousand new cases are diagnosed per year, with 36% of these being diagnosed with extrapulmonary TB.[5]

Phlyctenulosis, conjunctival granulomas, and granulomatous anterior uveitis are the most common anterior segment presentations of ocular TB. The diagnosis of ocular TB can be made either by isolation of the organism on LJ medium or histopathologic staining methods of affected tissues or detection of the organism by PCR.

In general, corneal involvement is rare in TB. Kamal et al.[6] described bilateral interstitial keratitis as a presenting manifestation of ocular TB in a 17-year-old girl which responded to topical steroid and ATT. Probable tubercular antigen in aqueous humor causing delayed hypersensitivity reaction was attributed to be the cause.

Arora et al.[7] reported bilateral disciform keratitis as presenting feature of extrapulmonary TB in an 11-year-old girl which on further investigation revealed tubercular Pott's spine.

In our patient, it presented as PUK with multiple punctate scleral abscess. PUK is a potentially devastating disorder with crescent-shaped destructive inflammation at the margin of the corneal stroma. Adjacent conjunctival, episcleral, and scleral inflammation are also generally apparent.[8]

Bayraktutar et al.[9] reported a case of ocular TB with progressive unilateral corneal melting with subconjunctival nodules in a 47-year-old female. The diagnosis was confirmed by the detection of bacillus DNA with PCR in the biopsy specimen of subconjunctival nodule; however, Ziehl–Neelsen staining of the specimen was negative for AFB. It was suggested that though histopathology is negative for AFB, the biopsy specimen should be examined by PCR. In our patient, PCR could not be done due to insufficient samples.

Gupta et al.[10] isolated M. tuberculosis on histopathological examination of a case with Sweet's syndrome who presented with PUK and scleral nodules.

Deepali et al.[11] reported a case of multiple disc-shaped corneal stromal infiltrates with hypopyon, which showed no improvement with empirical therapy and later with supporting investigations started on ATT and showed a rapid response. Similar to this case, our patient was unresponsive to routine treatment for PUK. Clinical suspicion of TB along with supporting investigations prompted us to start ATT, to which the patient responded well.


  Conclusion Top


Ocular TB, though rare, should be kept in mind in the differential diagnosis of patients with such presentation not responding to the standard antimicrobial therapy, especially in endemic regions such as India, as early diagnosis and treatment can prevent serious complications.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient (s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Shakarchi FI. Ocular tuberculosis: Current perspectives. Clin Ophthalmol 2015;9:2223-7.  Back to cited text no. 1
    
2.
Tabbara KF. Ocular tuberculosis: Anterior segment. Int Ophthalmol Clin 2005;45:57-69.  Back to cited text no. 2
    
3.
Alvarez S, McCabe WR. Extrapulmonary tuberculosis revisited: A review of experience at Boston city and other hospitals. Medicine (Baltimore) 1984;63:25-55.  Back to cited text no. 3
    
4.
Khadka P, Kharel R. Ocular tuberculosis: Clinicopathologic assortment and diagnostic challenges. J Clin Res Ophthalmol 2019;6:11-20.  Back to cited text no. 4
    
5.
Tabbara KF. Tuberculosis. Curr Opin Ophthalmol 2007;18:493-501.  Back to cited text no. 5
    
6.
Kamal S, Kumar R, Kumar S, Goel R. Bilateral interstitial keratitis and granulomatous uveitis of tubercular origin. Eye Contact Lens 2014;40:e13-5.  Back to cited text no. 6
    
7.
Arora R, Mehta S, Gupta D, Goyal J. Bilateral disciform keratitis as the presenting feature of extrapulmonary tuberculosis. Br J Ophthalmol 2010;94:809-10.  Back to cited text no. 7
    
8.
Galor A, Thorne JE. Scleritis and peripheral ulcerative keratitis. Rheum Dis Clin North Am 2007;33:835-54, vii.  Back to cited text no. 8
    
9.
Bayraktutar BN, Uçakhan-Gündüz Ö. Ocular tuberculosis with progressive unilateral corneal melting. Case Rep Ophthalmol 2015;6:293-7.  Back to cited text no. 9
    
10.
Gupta N, Chawla B, Venkatesh P, Tandon R. Necrotizing scleritis and peripheral ulcerative keratitis in a case of Sweet's syndrome found culture-positive for Mycobacterium tuberculosis. Ann Trop Med Parasitol 2008;102:557-60.  Back to cited text no. 10
    
11.
Singhal D, Maharana PK, Sharma N, Titiyal JS. Immune stromal keratitis: A rare ocular presentation of tuberculosis. BMJ Case Rep 2018;2018:bcr2017222571. doi: 10.1136/bcr-2017-222571.  Back to cited text no. 11
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]



 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Abstract
Introduction
Case Report
Discussion
Conclusion
References
Article Figures

 Article Access Statistics
    Viewed270    
    Printed22    
    Emailed0    
    PDF Downloaded34    
    Comments [Add]    

Recommend this journal


[TAG2]
[TAG3]
[TAG4]