Kerala Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 32  |  Issue : 1  |  Page : 36--40

Prostaglandin-associated periorbitopathy: A prospective study in Indian eyes


M Manju, Marian Pauly 
 Department of Orbit and Oculoplasty, Giridhar Eye Institute, Kochi, Kerala, India

Correspondence Address:
Dr. M Manju
D 501, Purva Eternity, Athani, Kakkanad, Ernakulam - 682 030, Kerala
India

Context: Prostaglandin analogs (PGAs) are commonly used antiglaucoma medications in the current era. The purpose of this study is to monitor the periorbital changes in patients started on topical PGA. Aim: The aim of this study is to study the periorbital changes in patients on PGA eye drops. Settings and Design: It is a prospective, uncontrolled, nonrandomized study. Subjects and Methods: During the initial visit, periorbital area was assessed by ptosis, proptosis, and lash length measurement. Color photography of periocular area was taken using a well-illuminated background for documentation and comparison. All the clinical assessments and color photography were repeated after 6 months. Statistical Analysis Used: Data were analyzed using the SPSS software version 16.0 and Microsoft Excel 2007. Results: Six eyes (9.5%) in the initial evaluation and 22 eyes (34.9%) in the follow-up visit showed periocular hyperpigmentation. There was a statistically significant increase in periocular hyperpigmentation with a P < 0.001. Two eyes in the initial evaluation and 23 eyes in the follow-up visit had deepening of the upper eyelid sulcus (DUES). There was a statistically significant increase in DUES with a P < 0.001. Of 63 eyes, 41 eyes (65%) developed prostaglandin-associated periorbitopathy (PAP) at the end of 6 months, and there is a statistically significant increase in the development of PAP after 6 months' P < 0.001. Conclusions: This study demonstrated a statistically significant increase in periorbital changes within 6 months of PGA use. Patients should be informed about the periorbital changes that could happen, and their cosmetic concerns should be addressed properly.


How to cite this article:
Manju M, Pauly M. Prostaglandin-associated periorbitopathy: A prospective study in Indian eyes.Kerala J Ophthalmol 2020;32:36-40


How to cite this URL:
Manju M, Pauly M. Prostaglandin-associated periorbitopathy: A prospective study in Indian eyes. Kerala J Ophthalmol [serial online] 2020 [cited 2020 Sep 26 ];32:36-40
Available from: http://www.kjophthal.com/article.asp?issn=0976-6677;year=2020;volume=32;issue=1;spage=36;epage=40;aulast=Manju;type=0