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Year : 2020  |  Volume : 32  |  Issue : 1  |  Page : 56-59

Efficacy of brinzolamide 1% / brimonidine 0.2% fixed combination versus brimonidine 0.2% / timolol 0.5% fixed combination in patients with primary open-angle glaucoma: A comparative study

Department of Ophthalmology, Government Medical College, Patiala, Punjab, India

Correspondence Address:
Dr. Harvinder Nagpal
Department of Ophthalmology, Government Medical College and Hospital, Patiala - 147 001, Punjab
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/kjo.kjo_83_19

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Purpose: The aim of the study was to compare the intraocular pressure (IOP)-lowering efficacy of brinzolamide 1%/brimonidine tartrate 0.2% fixed combination versus brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination.Materials and Methods: A prospective, randomized, comparative, interventional study was conducted on forty patients of primary open-angle glaucoma attending the outpatient department of the department of ophthalmology at a tertiary institution in North India. Patients fulfilling the inclusion criteria and having none of the exclusion criteria were enrolled in the study after obtaining written informed consent. Patients were then randomized into two groups (Groups 1 and 2) with twenty patients in each group. Group 1 patients were given a brinzolamide 1%/brimonidine tartrate 0.2% fixed drug combination (BBFC) one drop twice daily and Group 2 patients were given a brimonidine tartrate 0.2%/timolol maleate 0.5 % fixed drug combination (BTFC) one drop twice daily for 6 weeks, and IOP was recorded at baseline and after 6 weeks at 9 am and 11 am.Results: The mean age was 61.05 years in Group 1 and 60.20 years in Group 2; there were 11 males in Group 1 and 14 males in Group 2, and the rest were female. Baseline mean IOP values were similar among treatment groups at all time points. At 6 weeks, the mean IOP of Group 1 was 18.32 mmHg and Group 2 was 18.45 mmHg with a reduction of 7.58 mmHg (29.26%) and 8.15 mmHg (31.83%) in Group 1 and Group 2, respectively. The difference in the IOP lowering at the end of the study between the two groups was not statistically significant (P > 0.05). Conclusion: Our study shows that BBFC seems to be an effective, safe, noninferior, and β-blocker-free fixed combination.

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