|LETTER TO EDITOR
|Year : 2019 | Volume
| Issue : 1 | Page : 81
Little Flower Hospital and Research Centre, Angamaly, Kerala, India
|Date of Web Publication||15-Apr-2019|
K R Reesha
Little Flower Hospital and Research Centre, Angamaly, Kerala
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Reesha K R. Neovascular glaucoma. Kerala J Ophthalmol 2019;31:81
I would like to congratulate the authors for doing excellent work on “Neovascular glaucoma (NVG)” in the last issue of KJO by Saikumar et al. The authors have clearly highlighted the various aspects of this subject including the management. Is there any role for intracameral anti-vascular endothelial growth factor (VEGF) in NVG?
As mentioned clearly in the article, VEGF plays a major part in mediating active intraocular neovascularization in patients with ischemic retinal diseases. VEGF and insulin growth-1 factors are produced locally in the human eye by a variety of cells, including Mueller cells, retinal pigment epithelial cells, retinal capillary pericytes, endothelial cells, and ganglion cells. VEGF is sufficient to produce iris neovascularization in a nonhuman primate. Neovascularization was consistent with the increase of insulin growth-1 factor and induction of VEGF expression in the retinal glial cells. Insulin growth-1 factor accumulated in aqueous humor may cause rubeosis iridis, and subsequently, adhesions between the cornea and iris may block aqueous humor drainage. The concentration of VEGF can decline after the regression of iris neovessels. The nonpigmented ciliary epithelium is an important site of VEGF synthesis in patients with NVG. In fact, a recent study considered the ciliary epithelium as an additional focus of treatment in the management of NVG, especially in eyes that were not responsive to panretinal photocoagulation.
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Conflicts of interest
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| References|| |
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